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December 1976

Infections Complicating Orthotopic Liver TransplantationA Study Emphasizing Graft-Related Septicemia

Author Affiliations

From the Veterans Administration Hospital, the departments of surgery and pediatrics, University of Colorado Medical Center, Denver (Drs Schröter, Hoelscher, Putnam, Hansbrough, and Starzl); and the Department of Pathology, St Mary's Hospital and Medical School, London (Dr Porter).

Arch Surg. 1976;111(12):1337-1347. doi:10.1001/archsurg.1976.01360300027004

• In 93 recipients of 102 orthotopic liver homografts, the incidence of bacteremia or fungemia exceeded 70%. The graft itself was usually an entry site for systemic infection after both immunologic and nonimmunologic parenchymal injury, especially if there was defective biliary drainage. The role of the homograft itself as the special infectious risk factor has prompted increased use of defunctionalized jejunal Roux limbs to reduce graft contamination. It has also stimulated very aggressive postoperative diagnostic efforts to rule out remedial mechanical complications of the transplant.

(Arch Surg 111:1337-1347, 1976)