January 1977

The Ultrastructure of Collagen: Its Relation to the Healing of Wounds and the Management of Hypertrophic Scar

Author Affiliations

Brookline, Mass


edited by J. J. Lonacre, 549 pp, Charles C. Thomas Publisher, 1976.

Arch Surg. 1977;112(1):103. doi:10.1001/archsurg.1977.01370010105034

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This volume is based on a symposium held in 1973 at the Research Institute of the Children's Hospital of Cincinnati under the chairmanship of J. J. Longacre, a noted plastic surgeon, recently deceased.

The spectrum of topics is much broader than one might deduce from the somewhat misleading title. In fact, the major criticism is the disparity of subjects fitted under the rubric of "ultrastructure of collagen." Yet, this defect is more than compensated by the amount of intriguing information. There are chapters on wound sepsis, the influence of age on healing, long-term follow-up studies of meshed split-thickness grafting in burns, the effect of pressure on scars, the biological basis of Langer lines, the role of oxygen in bone healing, the control of mitosis in wound healing, as well as numerous articles on collagen, its structure, biochemistry, and role in "normal" scars as well as in keloids and hypertrophic scars.

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