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March 1977

Colonic NeoplasmsTissue Estrogen Receptor and Carcinoembryonic Antigen

Author Affiliations

From the Vince Lombardi Colon Clinic, Milwaukee County General Hospital; the Department of Pathology, Columbia Hospital, Milwaukee; the Veterans Administration Hospital, Wood, Wis; and the Department of Surgery, Medical College of Wisconsin, Milwaukee.

Arch Surg. 1977;112(3):240-241. doi:10.1001/archsurg.1977.01370030012002

• Estrogen receptor protein was found in 24% of colonic neoplasms. Presence of estrogen receptor activity was independent of age or sex of the patient, state of differentiation or spread of the tumor, and concentration of carcinoembryonic antigen in the tumor. Estrogen receptor activity in colon tumors probably reflects novel protein synthesis resulting from dedifferentiation. Measurement of tumor estrogen receptor protein and carcinoembryonic antigen may have discriminatory value in the patient with metastatic adenocarcinoma and an unknown primary neoplasm.

(Arch Surg 112:240-241, 1977)