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Article
December 1977

An Intracorporeal (Abdominal) Left Ventricular Assist DeviceInitial Clinical Trials

Author Affiliations

From the Division of Surgery and the Cardiovascular Surgical Research Laboratories of the Texas Heart Institute, St Luke's Episcopal and Texas Children's Hospitals, Houston.

Arch Surg. 1977;112(12):1442-1451. doi:10.1001/archsurg.1977.01370120032003
Abstract

• We have initiated clinical trials with an intracorporeal (abdominal) partial artificial heart and ten preterminal postcardiotomy patients have been studied. During profound left ventricular failure, the device captures the entire cardiac output from the apex of the left ventricle at low pressures (20 to 40 mm Hg) and ejects (at 80 to 150 mm Hg) into the infrarenal abdominal aorta; the biological aortic valve opens only intermittently and the entire systemic circulation is pump generated. The device is six to ten times more effective than intra-aortic balloon pumping in man and has maintained systemic perfusion during clinical asystole and ventricular fibrillation. We have documented that the profoundly depressed postcardiotomy left ventricle, initially incapable of ejection, can recover during total left ventricular unloading with the abdominal left ventricular assist device support over a seven-day period.

(Arch Surg 112:1442-1451, 1977)

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