May 1978

Protective Effects of Adenosine Triphosphate Administration in Burns

Author Affiliations

From the Surgical and Pathology Service of the Shriners Burns Institute and the Massachusetts General Hospital; the Department of Surgery, Harvard Medical School, Boston (Drs Burke and Trelstad); and the Faculty of Medicine, Cairo (Dr Zaki).

Arch Surg. 1978;113(5):605-610. doi:10.1001/archsurg.1978.01370170067013

• The effects of intramuscular adenosine triphosphate (ATP) administration after thermal skin injury on the ATP content and morphology of the liver and heart were studied in male Sprague-Dawley rats. The results showed that exogenous ATP injected during the early post-burn period could restore the ATP content of the liver and heart to near normal values and modify the burn-related morphological alterations in the liver.

(Arch Surg 113:605-610, 1978)