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May 1978

Acidification of Rat Colon With LactuloseIts Effects on the Healing of Colonic Anastomoses

Author Affiliations

From the Departments of Surgery, Veterans Administration Hospital (Drs Charoenkul, McElhinney, and Hodgson), Bronx, NY, and the Mount Sinai School of Medicine, City University of New York (Drs Hodgson and McElhinney), New York.

Arch Surg. 1978;113(5):618-620. doi:10.1001/archsurg.1978.01370170080016

• Preoperative preparation of rats with lactulose, 2.5 ml/kg of a 52.5% w/w solution, for two days resulted in increased bursting pressure and bursting wall tension of low colonic anastomoses three days postoperatively when compared with unprepared controls (85.8, viz, 36.1 mm Hg and 0.55, viz, 0.19 dynes/cm × 10−5). After seven days, there was no appreciable difference in the rats with colonic acidification and in the controls.

(Arch Surg 113:618-620, 1978)