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Article
July 1978

Severe Complications of Intralesional BCG Therapy in an Unsensitized PatientCase Report and Clinical Implications

Author Affiliations

From the Surgery Branch (Drs Jessup and Cohen), National Cancer Institute, National Institutes of Health, Bethesda, Md, and Department of Surgery, University of Illinois at the Medical Center, Chicago (Dr Felix).

Arch Surg. 1978;113(7):893-896. doi:10.1001/archsurg.1978.01370190115025
Abstract

• Since the introduction of BCG intralesional immunotherapy for melanoma, severe complications, including death, have been reported after treatment in hypersensitized individuals. This is a case report of BCG dissemination with ulceration, skin necrosis, lymphadenitis, and abscess formation following the first intralesional injection of a minimal dose of BCG in a PPD-negative patient. The case demonstrates that severe complications can occur in patients who are not hypersensitized, anergic, or debilitated or who have been treated multiple times. This patient's complication further suggests that migration of BCG after intralesional therapy may play a role in the regression of uninjected nodules seen in some patients.

(Arch Surg 113:893-896, 1978)

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