September 1978

Penetration of Clindamycin Into the Human Appendix

Author Affiliations

From the Departments of Medicine (Dr Berger) and Surgery (Drs Leslie, Raciti, and Kazarian), the New York Medical College, New York; and the Department of Medicine, Tufts-New England Medical Center (Dr Barza and Ms Kane), Boston.

Arch Surg. 1978;113(9):1094-1095. doi:10.1001/archsurg.1978.01370210076010

• Clindamycin penetrated extremely well into inflamed (19) and normal (one) appendices. Average levels in appendiceal tissue taken 26 to 300 minutes after a single intravenous dose were 154% of the simultaneous serum concentration.

(Arch Surg 113:1094-1095, 1978)