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January 1979

Cimetidine in the Management of Metabolic Alkalosis Induced by Nasogastric Drainage

Author Affiliations

From the Department of Medicine, University of California, Irvine, Orange, Calif.

Arch Surg. 1979;114(1):70-74. doi:10.1001/archsurg.1979.01370250072015

• Metabolic alkalosis resulting from nasogastric drainage is a well recognized and potentially serious clinical problem. In the postoperative patient with acute renal failure, the management of the metabolic alkalosis is particularly difficult, and established modalities of therapy are sometimes ineffective and can be hazardous to the patient. In this article, we report on the successful use of cimetidine (an H2-receptor antagonist) as an adjunct in the treatment of severe metabolic alkalosis in a postsurgical renal failure patient. To our knowledge, this is the first reported successful use of cimetidine in the treatment of metabolic alkalosis due to gastric acid loss.

(Arch Surg 114:70-74, 1979)