March 1979

Gastric Tissue Prostaglandin LevelsEffect of Vagotomy

Author Affiliations

From the Department of Surgery, Veterans Administration Hospital, and the University of California, San Diego.

Arch Surg. 1979;114(3):331-332. doi:10.1001/archsurg.1979.01370270101019

• To determine tissue prostaglandin levels in antrum and fundus and to examine the effect of vagotomy and distention on tissue prostaglandin levels, truncal and parietal cell vagotomies were performed on rats that were killed at 2, 4, and 6 weeks postoperatively with antral and fundic prostaglandin E1 levels being determined. The fundus has considerably higher levels of prostaglandin than the antrum. No differences after any type of vagotomy however, were noted. It cannot be concluded from this study that increased prostaglandin levels result from vagotomy.

(Arch Surg 114:331-332, 1979)