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May 1979

Ecthyma GangrenosumSurvival With Individualized Antibiotic Therapy

Author Affiliations

From the Department of Surgery, (Drs Solem, Zaske, and Strate) School of Medicine and College of Pharmacy (Dr Zaske), St Paul-Ramsey Medical Center, St Paul, and the University of Minnesota, Minneapolis.

Arch Surg. 1979;114(5):580-583. doi:10.1001/archsurg.1979.01370290030005

• Five burn patients with ecthyma gangrenosum were treated with gentamicin sulfate in an individualized aminoglycoside regimen. Dosages greater than the currently recommended 3 to 5 mg/kg/day were necessary and ranged from 15 to 30 mg/kg/day. These increased dosages cannot be used routinely but only as serum level data indicate the need. Four of the five patients survived their course of ecthyma gangrenosum. The single fatality received a much smaller dosage of gentamicin as compared with the other four patients. No ototoxic or nephrotoxic reactions were noted in any of the patients.

(Arch Surg 114:580-583, 1979)