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Article
August 1979

Ultrasonography and Tumor-associated AntigensThe Concept of Combining Noninvasive Tests in the Screening for Pancreatic Cancer

Author Affiliations

From the Departments of Surgery (Drs Mackie, Cooper, Lewis, and Moossa) and Radiology (Dr Bowie), University of Chicago Hospitals and Clinics, Chicago.

Arch Surg. 1979;114(8):889-892. doi:10.1001/archsurg.1979.01370320021004
Abstract

• A total of 134 patients suspected of having pancreatic cancer were given preoperative ultrasonic examinations. A total of 54 cases had a final diagnosis of pancreatic cancer histologically confirmed. The diagnostic sensitivity and specificity of the ultrasonographies were 76% and 91% or 87% and 74%, depending on whether doubtful results were called abnormal or normal. "Doubtful" results were defined as those that stated that pancreatic cancer was "possible" or "could not be excluded." When these results were divided into abnormal and normal groups on the basis of the patients' preoperative serum carcinoembryonic antigen and pancreatic oncofetal antigen levels, the sensitivity and specificity of the combined tests may prove to be a more accurate means of screening patients for pancreatic cancer than ultrasonography alone.

(Arch Surg 114:889-892, 1979)

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