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July 1980

Common Bile Duct Pressure During Enflurane AnesthesiaEffects of Morphine and Subsequent Naloxone

Author Affiliations

From the Naval Regional Medical Center, Jacksonville, Fla. Dr Dedrick is now with the Harvard Medical School, Boston; Dr Tanner is now with Chippenham Anesthesia Associates, Inc, Richmond, Va; Dr Bushkin is now with the University of Florida College of Medicine, Gainesville.

Arch Surg. 1980;115(7):820-822. doi:10.1001/archsurg.1980.01380070014003

• In ten otherwise healthy patients undergoing cholecystectomy and cholangiography, morphine sulfate, in a dose of 2.5 mg/70 kg body weight, significantly elevated common bile duct pressure, as measured by water manometry, two and five minutes after intravenous injection. There was no added effect from an additional 7.5 mg/70 kg, measured two and five minutes after injection. Naloxone hydrochloride, in a dose of 1.0 mg/70 kg body weight, quickly reversed the increase in pressure caused by the morphine. Radiographic contrast material passed into the duodenum in every patient after administration of naloxone.

(Arch Surg 115:820-822, 1980)