• Postoperative outcomes of 31 afebrile patients who had responded to treatment for intra-abdominal sepsis were compared based on the presence or absence of leukocytosis (WBC count > 10,000/cu mm) at the conclusion of antibiotic therapy. In 68% of the patients who had leukocytosis, postoperative septic complications developed within two months of their operation. In patients without leukocytosis, complications developed in only 8.3%. Afebrile patients who exhibit leukocytosis but have responded clinically to treatment are at risk for postoperative infection and multisystem failure.
(Arch Surg 115:918-921, 1980)
Lennard ES, Minshew BH, Dellinger EP, Wertz M. Leukocytosis at Termination of Antibiotic TherapyIts Importance for Intra-abdominal Sepsis. Arch Surg. 1980;115(8):918-921. doi:10.1001/archsurg.1980.01380080016003