November 1980

Splenic Regeneration

Author Affiliations

Huntington, WVa

Arch Surg. 1980;115(11):1401. doi:10.1001/archsurg.1980.01380110133022

To the Editor.—Alvarez and Greco (Archives 1980;115:772-775) have shown that a splenic remnant with intact blood supply is superior to autotransplanted splenic fragments in restoring splenic mass. Studies in our laboratory demon strate that the spleen can regenerate after partial splenectomy and does so quite rapidly.

Twenty 6-week-old CD2F1 female mice were killed; spleens were removed and weighed. Mean splenic weight was 98.75 mg. Partial splenectomy was performed on 80 mice using ether anesthesia. Fifty percent of the spleen was removed, leaving a remnant supplied by the hilar vessels. Animals were killed on day 0,10,28, or 112. All splenic tissue was removed and weighed. Histopathologic specimens were taken. Mean splenic weights were as follows: day 0, 47.13 mg; day 10, 69.06 mg; day 28, 78.15 mg; day 112, 78.48 mg. Morphologically, specimens taken on days 10, 28, and 112 were indistinguishable. By day 10, animals had

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