January 1981

Prospective Use of Xenon Xe 133 Clearance for Amputation Level Selection

Author Affiliations

From the Departments of Surgery (Drs Moore and Malone and Ms Childers) and Radiology (Nuclear Medicine) (Dr Patton), University of Arizona Health Science Center, and the Veterans Administration Hospital (Drs Henry and Daly), Tucson, Ariz. Dr Moore is now with the University of California at Los Angeles.

Arch Surg. 1981;116(1):86-88. doi:10.1001/archsurg.1981.01380130062014

• Xenon Xe 133 clearance was used to select the most distal amputation level that would allow sufficient blood flow for healing. Capillary blood flow was first measured at the most distal potential amputation level, then at successive proximal levels until an amputation site was found that had a capillary skin blood flow rate greater than or equal to 2.6 mL/min/100 g of tissue. Xenon Xe 133 in saline (100 to 500 mCi) was injected intracutaneously at each level, and flow rates were determined using a gamma camera interfaced with a computer system programmed for the Ketty-Schmidt formula modified for capillary blood flow. There were 45 cases, including one toe, six transmetatarsal, five Syme's 25 below-knee, four knee disarticulation, three above-knee, and one hip disarticulation amputation. All amputations in patients with flow rates exceeding 2.4 mL/ min/100 g of tissue healed, with two exceptions.

(Arch Surg 116:86-88, 1981)