• A 6-year-old girl with unresectable and metastatic neuroblastoma had a complete remission with irradiation to the primary tumor and systemic administration of cyclophosphamide. The patient was disease-free for 16 years but had an explosive recurrence of tumor six weeks after a hysterectomy. Although no clear cause-and-effect relationship exists between the surgery and the recurrence, this case illustrates that a recurrence is possible after a long disease-free interval. Diagnostic and therapeutic procedures in such patients should be undertaken with caution.
(Arch Surg 1981;116:474-475)
Sutherland CM, Krementz ET, Harkin JC, Culotta V. Recurrence of Neuroblastoma Following Prolonged Remission. Arch Surg. 1981;116(4):474-475. doi:10.1001/archsurg.1981.01380160084018