• Changes in the ratio of acetoacetate to 3-hydroxybutyrate (the ketone body ratio) in arterial blood were investigated after massive liver resection in patients and rabbits. In a patient who had had a successful hepatectomy, the blood ketone body ratio decreased rapidly after the operation and then returned to the preoperative level; whereas in a patient who had had an unsuccessful hepatectomy, the blood ketone body ratio did not decrease rapidly after the operation. In 70% hepatectomized rabbits, the blood ketone body ratio decreased maximally nine hours after hepatectomy and then returned gradually to a normal level. The blood ketone body ratio paralleled the hepatic energy charge after 70% hepatectomy in rabbits. The measurement of the blood ketone body ratio is very useful for evaluation of the energy status of the remnant liver.
(Arch Surg 1981;116:781-785)
Ukikusa M, Ozawa K, Shimahara Y, Asano M, Nakatani T, Tobe T. Changes in Blood Ketone Body RatioTheir Significance After Major Hepatic Resection. Arch Surg. 1981;116(6):781-785. doi:10.1001/archsurg.1981.01380180039008