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Article
March 1982

Malignant HyperthermiaCurrent Concepts

Author Affiliations

From the Division of Pediatric Surgery, University of Miami School of Medicine. Dr Marchildon is now with the College of Medicine and Dentistry of New Jersey/Rutgers Medical School, Camden.

Arch Surg. 1982;117(3):349-351. doi:10.1001/archsurg.1982.01380270063014
Abstract

• At least three myopathies have been associated with malignant hyperthermia (MH). The clinical manifestations of MH are variable and depend on the nature of the underlying myopathy and the anesthetic agents administered. Unless muscle relaxants are used, fever and muscle rigidity may be delayed at onset. Tachycardia and tachypnea are often the earliest manifestations and can occur immediately or several hours into a surgical procedure. Life-threatening cardiac arrhythmias may result from hyperkalemia and acidosis. A hyperthermic reaction developed in an 8-year-old boy with a family history of Duchenne's muscular dystrophy one hour after induction of anesthesia. Temperature elevation and muscle rigidity were minor components of the condition. Determination of arterial blood gas concentrations and the serum potassium level established the diagnosis and enabled the start of lifesaving therapy.

(Arch Surg 1982;117:349-351)

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