July 1982

Chemotherapy Before and After Mastectomy in Stage III Breast Cancer

Author Affiliations

From the Departments of Neoplastic Diseases (Dr Perloff and Surgery (Dr Lesnick), Mount Sinai School of Medicine, New York. Dr Perloff is now with Columbia University College of Physicians and Surgeons, New York.

Arch Surg. 1982;117(7):879-881. doi:10.1001/archsurg.1982.01380310005002

• Seventeen patients with stage III breast cancer were treated by modified radical mastectomy preceded and followed by multiagent cytotoxic chemotherapy. The preoperative treatment resulted in a decrease in size of the primary tumor, facilitating the subsequent surgical procedure. There were no serious surgical complications. Wound healing was uneventful. Median disease-free survival time was 29 months and median survival time was 40+ months. Six of the 17 patients are living free of recurrence from more than 33 to more than 79 months after initial therapy.

(Arch Surg 1982;117:879-881)