• In 30 cases of colonic neoplasia associated with melanosis coli, proliferating or neoplastic colonic epithelium was notable within the melanotic colons by virtue of a striking absence of pigmentation. Microscopically this characteristic was found to be due to an absence or diminution of pigment-laden macrophages in the lamina propria underlying such lesions. Therefore, the absence of pigment-laden macrophages can be considered a marker for abnormally proliferating epithelium. This characteristic may denote a cellular or humoral change mediated by macrophages in association with neoplastic epithelium.
(Arch Surg 1983;118:62-64)
Morgenstern L, Shemen L, Allen W, Amodeo P, Michel SL. Melanosis ColiChanges in Appearance When Associated With Colonic Neoplasia. Arch Surg. 1983;118(1):62-64. doi:10.1001/archsurg.1983.01390010048011