• During 31 months of study, 808 patients with polymicrobial surgical infection were randomized for antibiotic therapy between a third-generation cephalosporin (moxalactam disodium , cefotaxime sodium , and cefoperazone sodium ) and the combination of gentamicin sulfate plus clindamycin (393). Results based on antibiotic therapy included the following: cure in 83% given cephalosporin, 73% with antibiotic combination; control but recurrent sepsis in 7% and 15%; and failure in 4% and 8%, respectively. Such data support the tenet that third-generation cephalosporins are at least equal, if not superior, to the combination of gentamicin plus clindamycin for treatment of polymicrobial surgical sepsis.
(Arch Surg 1983;118:193-200)
Stone HH, Strom PR, Fabian TC, Dunlop WE. Third-Generation Cephalosporins for Polymicrobial Surgical Sepsis. Arch Surg. 1983;118(2):193-200. doi:10.1001/archsurg.1983.01390020047009