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Article
March 1983

Staphylococcus in Toxic Shock Syndrome and Other Surgical InfectionsDevelopment of New Bacteriophages

Author Affiliations

From the Surgical Research Bacteriology Laboratory (Drs Altemeier and Bjornson and Ms Lewis) and the Department of Pathology and Laboratory Medicine (Dr Staneck), University of Cincinnati Medical Center and the Department of Microbiology, University of Minnesota Medical School, Minneapolis (Dr Schlievert).

Arch Surg. 1983;118(3):281-284. doi:10.1001/archsurg.1983.01390030013002
Abstract

• Recent studies of Staphylococcus aureus isolates from patients with toxic shock syndrome (TSS) have shown the dominance of phage type 29/52 with the capacity to produce pyrogenic exotoxin C and enterotoxin F. They also showed that 29% of the isolates were nontypable and 90% of them had similar toxigenic properties. The existence of unknown and important phages in this disease was postulated. Five new phages were then developed and used for typing three groups of staphylococcal isolates: 236 from patients with TSS, 67 from patients without TSS, and 159 from patients with infected burns. Results showed a high correlation between the lytic action of the new phages and the 29/52 phages, and an additional typing capability in 35% of the previously nontypable TSS isolates, emphasizing further the potential of bacteriophage typing of S aureus in these infections.

(Arch Surg 1983;118:281-284)

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