• We compared the results of dihydroergotamine mesylate administered with low-dose heparin sodium with those of low-dose heparin given alone in a randomized trial based on 181 patients who underwent major abdominal surgery. We found no significant difference in the incidence of thromboembolism between the two groups but a higher incidence of abnormal fibrinogen uptake test results in patients given heparin alone. There was no difference in hemoglobin levels and the number of blood transfusions. We concluded that there is little, if any, clinical advantage in adding dihydroergotamine to low-dose heparin to prevent thromboembolic complications in patients who have undergone major abdominal surgery.
(Arch Surg 1983;118:926-928)
Wille-Jørgensen P, Kjaergaard J, Thorup J, Jørgensen T, Fogh J, Munck O, Andersen B. Heparin With and Without Dihydroergotamine in Prevention of Thromboembolic Complications of Major Abdominal SurgeryA Randomized Trial. Arch Surg. 1983;118(8):926-928. doi:10.1001/archsurg.1983.01390080034010