February 1984

Increased Susceptibility to Infection Related to Extent of Burn Injury

Author Affiliations

From the US Army Institute of Surgical Research, Fort Sam Houston, Tex. Dr Yurt is now with the New York Hospital—Cornell Medical Center.

Arch Surg. 1984;119(2):183-188. doi:10.1001/archsurg.1984.01390140047008

• A model of burn wound sepsis in which the mortality caused by infection was significantly greater after a 60% total body surface area (TBSA) burn than after a 30% TBSA burn was developed in the rat. In rats that sustained a 60% TBSA burn (30% partial plus 30% full thickness), the 30% TBSA partial-thickness burn that was inoculated with Pseudomonas aeruginosa strain 59-1244 developed invasive wound infection (>105 colony-forming units per gram of tissue). Infection did not develop in rats that had a 30% TBSA partial-thickness burn inoculated, without additional injury. The additional burn in the rats with a 60% TBSA burn seemed to affect the development of infection in the partial-thickness wound and the overall outcome by a mechanism other than by infection of the full-thickness wound itself. Autopsy confirmed that mortality was caused by sepsis.

(Arch Surg 1984;119:183-188)