[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.87.114.118. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
April 1984

Aggressive Surgical Therapy After Irradiation Failure in Treatment of Cancer of the Oral Tongue

Author Affiliations

From the Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Minnesota Hospitals, Minneapolis, and the Minneapolis Veterans Administration Hospital.

Arch Surg. 1984;119(4):394-399. doi:10.1001/archsurg.1984.01390160030007
Abstract

• Fifty-three consecutive unrandomized patients with squamous cell cancer of the oral tongue were retrospectively studied to compare the results of an aggressive surgical approach performed as primary therapy or as salvage after irradiation failure. Twenty-five patients underwent surgery primarily, while 23 of 28 patients treated with curative irradiation required surgical salvage. Tumor staging was equivalent between the two groups. Local recurrences at the site of origin of the tumor within two years postoperatively were significantly more frequent in salvage patients (10.0%) than in primary surgical patients (5.5%). Cervical lymph node recurrences within five years were more frequent in the salvage surgery group (74.8% V 36.7%). Systemic metastases developed in a similar proportion in both groups. Determinate fiveyear survivals were nearly identical (55.2% v 55.5%). Although recurrence rates were significantly higher after irradiation and salvage surgery, an aggressive surgical effort in patients who are irradiation failures can result in five-year survival rates matching those of surgical patients.

(Arch Surg 1984;119:394-399)

×