• Single doses of clindamycin hydrochloride and gentamicin sulfate given preoperatively, combined with intraoperative topical application of povidone-iodine were given to patients with perforated or gangrenous appendicitis. The incidence of wound sepsis was reduced from 36% to 5%; severe infections were reduced from 25% to 0% when compared with a control untreated group of patients. When used alone, povidone-iodine had little effect in these patients. No toxic effects of the antibiotics or antiseptic were recorded nor were any resistant strains of pathogenic organisms grown from cultures.
(Arch Surg 1984;119:909-911)
Sherlock DJ, Ward A, Holl-Allen RTJ. Combined Preoperative Antibiotic Therapy and Intraoperative Topical Povidone-IodineReduction of Wound Sepsis Following Emergency Appendectomy. Arch Surg. 1984;119(8):909-911. doi:10.1001/archsurg.1984.01390200029007