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May 1985

Relation of Free Silicone to Human Breast Carcinoma

Author Affiliations

From the Departments of Surgery (Drs Morgenstern, Gleischman, Michel, and Knight and Mr Rosenberg) and Pathology (Dr Goodman), Cedars-Sinai Medical Center, Los Angeles.

Arch Surg. 1985;120(5):573-577. doi:10.1001/archsurg.1985.01390290051008

• Of 12 women with carcinoma of the breast and coexistent silicone mastopathy, nine had had injections of liquid silicone for breast augmentation; three had leaking silicone-gel prostheses. The clinical findings indicated that early diagnosis was obscured by the silicone-induced mastopathy, which rendered the interpretation of physical findings and mammograms difficult. The pathologic findings were suggestive of a possible adverse effect of the presence of free silicone within the breast tissue, axillary nodes, and axillary fat. Although no causal relationship between silicone and breast carcinoma is implied, a heightened awareness of the possible coexistence of silicone mastopathy and breast carcinoma is necessary.

(Arch Surg 1985;120:573-577)