June 1985

Cefoxitin Concentration in Wound Fluid

Author Affiliations

From the Department of Urology, Thomas Jefferson University, Philadelphia (Dr Bagley), and the Department of Surgery, Division of Plastic and Reconstructive Surgery, Wayne State University Medical Center, Detroit (Drs Zachary, Robson, and Heggers).

Arch Surg. 1985;120(6):752-753. doi:10.1001/archsurg.1985.01390300090016

• The concentration of cefoxitin was determined in fluid obtained from human surgical wounds during the first post-operative day. Intravenous administration of cefoxitin sodium at a dosage of 1 or 2 g every six hours rapidly produced wound-fluid concentrations greater than the minimal inhibitory concentration for most susceptible organisms. After three hours, wound-fluid concentrations surpassed the serum concentrations of cefoxitin. The higher dosage resulted in higher wound-fluid levels.

(Arch Surg 1985;120:752-753)