August 1985

The Effect of Vitamin E on Experimentally Induced Peritoneal Adhesions in Mice

Author Affiliations

From the Departments of Surgery, Albert Einstein College of Medicine and the Montefiore Medical Center, Bronx, NY. Dr Seifter is also with the Department of Biochemistry, Albert Einstein College of Medicine.

Arch Surg. 1985;120(8):949-951. doi:10.1001/archsurg.1985.01390320073015

• Previous studies in our laboratory demonstrated that dietary supplementation with vitamin A enhances peritoneal adhesion formation in mice. Other researchers have shown that vitamin E antagonizes some effects of vitamin A in various systems, eg, wound healing. We investigated our hypothesis that dietary supplementation with vitamin E would decrease peritoneal adhesion formation. Adult mice were divided into the following groups: group 1, which ate a standard chow containing 65 IU of vitamin E per kilogram diet (twice the National Research Council's recommended daily allowance for normal mice); and group 2, which ate the same chow supplemented with vitamin E at 300 IU/kg diet (a nontoxic level). Following peritoneal ligation, all mice were killed on the tenth postoperative day and their peritoneal cavities examined for the presence and extent of adhesions. There was a statistically significant decrease in the incidence and degree of adhesions in the vitamin E—supplemented animals; these data supported our hypothesis.

(Arch Surg 1985;120:949-951)