December 1985

Early Somatostatinoma of the Papilla of the Duct of Santorini

Author Affiliations

From the Departments of Pathology (Dr Silverman) and Surgery (Drs Malone, Braasch, and Gongliang), Lahey Clinic Medical Center, Burlington, Mass, and the Department of Pathology, New England Medical Center, Boston (Dr Dayal). Dr Malone is now with the Department of Surgery, University of Massachusetts Medical Center, Worcester; Dr Gongliang, the Department of Surgery, No. 2 Hospital, Zhejiang Medical School, Hangchow, People's Republic of China.

Arch Surg. 1985;120(12):1381-1383. doi:10.1001/archsurg.1985.01390360047011

• We studied a patient with a very small somatostatinoma that arose from the prominence of the orifice of the duct of Santorini. The patient presented clinically with epigastric discomfort, marked loss of weight, diarrhea, exertional dyspnea, and chest pain. He flushed intermittently and had occasional tachycardia and hypertension. Levels of serum serotonin and urinary 5-hydroxyindoleacetic acid were normal. A small ampullary tumor was resected and identified by immunohistochemical staining to be a somatostatinoma. The patient had gained 6.75 kg and was essentially free of symptoms 16 months after surgery.

(Arch Surg 1985;120:1381-1383)