January 1986

Muramyl Dipeptide Enhances Survival From Experimental Peritonitis

Author Affiliations

From the Price Institute of Surgical Research (Dr Brown and Messrs Foshee and Pietsch) and the Department of Surgery (Dr Polk), University of Louisville School of Medicine.

Arch Surg. 1986;121(1):47-49. doi:10.1001/archsurg.1986.01400010053006

• Muramyl dipeptide is a nonspecific immunostimulant derived from Freund's complete adjuvant. We determined the effect of muramyl dipeptide on two separate animal models for peritonitis. We found that administration of muramyl dipeptide to rats undergoing cecal ligation and puncture significantly reduced mortality. Similarly, mice that underwent cecal ligation alone with muramyl dipeptide administration also had a statistically significant reduction in mortality compared with untreated controls.

(Arch Surg 1986;121:47-49)