January 1986

Effect of Transfusion on Immune Function in a Traumatized Animal Model

Author Affiliations

From the Department of Research, Shriners Burns Institute, Cincinnati (Drs Waymack, Tweddell, and Alexander and Mss Rapien and Garnett); and the Department of Surgery, University of Cincinnati (Drs Waymack and Alexander). Dr Tweddell is now with the Department of Surgery, New York University. Dr Waymack is the Surgical Infection Society—3M Research Fellow.

Arch Surg. 1986;121(1):50-55. doi:10.1001/archsurg.1986.01400010056007

• Blood transfusions repeatedly have been shown to prolong allograft survival, probably by stimulating suppressor T lymphocytes. The effects of transfusions on immune function in traumatized patients has not previously been investigated. We investigated the effects of transfusions on the immune system using a burned rat model. The transfusions were found to have no effect on the white blood cell counts, differential cell count, or neutrophil migration and bactericidal index. Those animals that received transfusions did exhibit impaired cell-mediated immunity and macrophage migration. Blood transfusions seem to increase further the immunosuppression seen with trauma and surgery.

(Arch Surg 1986;121:50-55)