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Article
June 1986

Acid and Gastrin Levels Following Pyloric-Preserving Pancreaticoduodenectomy

Author Affiliations

From the Departments of Surgery (Drs Pearlman and Stiegmann), Medicine (Dr Ahnen), and Pathology (Drs Schultz and Fink), Denver Veterans Administration Medical Center and University of Colorado Health Sciences Center, Denver.

Arch Surg. 1986;121(6):661-664. doi:10.1001/archsurg.1986.01400060055006
Abstract

• Acid and gastrin production after pyloric-preserving pancreaticoduodenectomy was evaluated in six patients. Five patients had low-normal basal and stimulated acid output; the sixth patient was achlorhydric. Fasting gastrin levels were less than 90 to 105 pg/mL (normal range) in five patients, three of whom had stimulated gastrin levels that remained below this range. Two patients had stimulated gastrin levels of 510 pg/mL and 205 pg/mL, respectively, within 15 minutes of eating; however, both levels returned to normal by 120 minutes' time. The sixth patient had mildly elevated fasting (105 pg/mL) and stimulated gastrin levels (160 to 200 pg/mL) throughout the test period. The results suggest that pyloric-preserving pancreaticoduodenectomy does not lead to either gastric hyperacidity or persistent hypergastrinemia.

(Arch Surg 1986;121:661-664)

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