• A 66-year-old lower-extremity amputee with an acute femoral artery occlusion was treated with low-dose (10 000 units/h) percutaneous constant-infusion streptokinase. At 48 hours after initiation of therapy, the patient experienced adult respiratory distress syndrome and died. A postmortem examination confirmed the diagnosis; laboratory studies reflected an increased level of fibrinolytic split products, thrombocytopenia, and a low level of fibrinogen.
(Arch Surg 1986;121:852-853)
Kerstein MD, Adinolfi MF. Pulmonary Dysfunction Associated With Streptokinase Therapy. Arch Surg. 1986;121(7):852-853. doi:10.1001/archsurg.1986.01400070122026