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November 1986

Imaging of Human Colorectal Adenocarcinoma With Indium-Labeled Anticarcinoembryonic Antigen Monoclonal Antibody

Author Affiliations

From the Department of General Oncologic Surgery (Drs Duda, J. Beatty, B. Beatty, Kemeny, Kokal, Riihimaki, Wagman, and Terz, and Mr Vlahos), the Divisions of Diagnostic Radiology (Drs Williams and Werner), Immunology (Drs Paxton and Shively), and Anatomic Pathology (Dr Sheibani), the City of Hope National Medical Center, Duarte, Calif.

Arch Surg. 1986;121(11):1315-1319. doi:10.1001/archsurg.1986.01400110107018

• Twenty patients with 21 primary colorectal adenocarcinomas were studied with 2 mCi (7.6 ×107 becquerels) of indium-labeled monoclonal antibody (200 μg) specific for carcinoembryonic antigen (CEA). Fifteen lesions (71%) were visualized by gamma camera scintigraphy at 48 hours postinjection. Tumors that were identified by immunoscintigraphy were large (38.10±17.76 cm3 vs 6.00±1.65 cm3), had a grossly fungating component, had a high content of CEA by enzyme immunoassay (12.9±3.6 μg/g vs 3.3±1.7 μg/g), and had an apical and/or intraluminal staining pattern on immunohistologic section. Patients whose tumors were visualized had a low serum CEA level (1.9±0.4 ng/mL vs 14.6± 8.0 ng/mL). Prospective selection of patients for follow-up imaging or therapy with radiolabeled monoclonal antibodies may be feasible using these measurements.

(Arch Surg 1986;121:1315-1319)