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February 1987

Inhibition of Lymphocyte Proliferation by Fluid-Phase C3b as Influenced by Macrophages

Author Affiliations

From the Departments of Surgery (Drs C. Ogle and Alexander) and Biological Chemistry (Dr J. Ogle), University of Cincinnati College of Medicine and Shriners Burns Institute (Mss Johnson and Keynton).

Arch Surg. 1987;122(2):234-238. doi:10.1001/archsurg.1987.01400140116016

• The effect of fluid-phase C3b on mitogen-induced lymphocyte proliferation in the presence and absence of macrophages was studied. In general, C3b inhibited the proliferation of lymphocytes when monocytes (macrophages) were present. The degree of inhibition by C3b was different for B and T lymphocytes and varied for different subpopulations of lymphocyte classes. In the absence of monocytes (macrophages), there was insignificant inhibition by C3b of lymphocyte proliferation, and thus the observed inhibition appeared to be due to the effect of C3b on the monocytes/macrophages present in the mixed lymphocyte preparations.

(Arch Surg 1987;122:234-238)