June 1987

Intraoperative Implantation Radiation Therapy Plus Lumpectomy for Carcinoma of the Breast

Author Affiliations

From the Departments of Surgery (Drs Jewell and Thomas) and Radiation Oncology (Drs Krishnan and Reddy), University of Kansas Medical Center, Kansas City; and the Department of Radiation Therapy, Thomas Jefferson University Hospital, Philadelphia (Dr Mansfield).

Arch Surg. 1987;122(6):687-690. doi:10.1001/archsurg.1987.01400180069013

• The preponderance of evidence indicates that lumpectomy plus radiation therapy produces the same survival as modified radical mastectomy in patients with early breast cancer and further suggests that the local failure rate may be lower in the patients who undergo irradiation. In this series, patients were treated with immediate implantation of the tumor bed with iridium Ir 192. There have been two recurrences in the breast from 110 breast cancers (44% had a clinical stage greater than T1, and 41% had axillary-node involvement) in 107 patients followed up for four to 52 months (25.8±13.3 months [mean±SD]). These preliminary data suggest that local treatment failure can be minimized by aggressive, immediate intraoperative implantation of the tumor bed with iridium Ir 192.

(Arch Surg 1987;122:687-690)