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October 1987

Resting Energy Expenditure of Host and Tumor Is Similar in Rats With Methylcholanthrene-Induced Sarcoma

Author Affiliations

From the Department of Surgery, University of Cincinnati Medical Center. Drs Freund and Muggia-Sullam are now with the Hebrew University—Hadassah Medical School, Jerusalem. Dr Kim is now with the Yonsei University College of Medicine, Seoul, Korea.

Arch Surg. 1987;122(10):1151-1152. doi:10.1001/archsurg.1987.01400220061012

• In the present study we assessed the resting energy expenditure of 30 free-feeding control and methylcholanthrene-induced sarcoma-bearing rats prior to and following surgical removal of the tumor. Tumor-bearing rats demonstrated carcass wasting and massive tumor growth. The resting energy expenditure data in our model suggest that neither the presence and growth of a tumor nor its removal significantly change resting energy expenditure beyond the normal range for non—tumor-bearing rats. We suggest that in the partition of energy costs between host and tumor, both carry a similar input, proportional to their relative weight, into the total combined resting energy expenditure of host and tumor.

(Arch Surg 1987;122:1151-1152)