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November 1987

Chromosomal Changes in Soft-Tissue SarcomasA New Diagnostic Parameter

Author Affiliations

From the Departments of Surgical Oncology (Dr Karakousis) and Genetics and Endocrinology (Drs Dal Cin, Turc-Carel, Limon, and Sandberg), Roswell Park Memorial Institute, Buffalo.

Arch Surg. 1987;122(11):1257-1260. doi:10.1001/archsurg.1987.01400230043007

• A cytogenetic study was performed on short-term cultures from fresh surgical specimens obtained from 41 patients with soft-tissue sarcomas of various histologic origins. The results demonstrated that myxoid liposarcomas (five tumors) were associated with a specific translocation between chromosomes 12 and 16 and that synovial sarcomas (six tumors) were associated with a specific translocation between the X chromosome and chromosome 18. These chromosomal data have been used to differentiate myxoid liposarcoma from other myxoid tumors exhibiting a noncharacteristic histologic picture, as well as to ascertain the diagnosis of synovial sarcoma in undifferentiated soft-tissue sarcomas. The results to date indicate that identification of specific chromosomal changes in sarcomas may provide a new diagnostic criterion for these tumors and possibly improve prognostication with regard to survival and response to treatment.

(Arch Surg 1987;122:1257-1260)