[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.167.156.247. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
December 1987

Colorectal CancerDukes' Stage, Tumor Site, Preoperative Plasma CEA Level, and Patient Prognosis Related to Tumor DNA Ploidy Pattern

Author Affiliations

From the Section of Colon and Rectal Surgery (Drs Scott and Beart), and Departments of Urology (Dr Lieber), Medical Oncology (Dr Moertel and Mr Cha), and Epidemiology (Dr Wieand and Mr Cha), Mayo Clinic/Foundation, Rochester, Minn.

Arch Surg. 1987;122(12):1375-1379. doi:10.1001/archsurg.1987.01400240021002
Abstract

• Flow cytometric DNA histograms of colorectal carcinomas from 264 patients were evaluated for the association of tumor site, Dukes' stage, tumor grade, and preoperative carcinoembryonic level with patient survival. The DNA nondiploid carcinomas were significantly more common from the left (descending and sigmoid) colon and the rectum. A poorer prognosis was found for patients with DNA nondiploid cancers than for patients with DNA diploid cancers. This was particularly true for patients with Dukes' stages B2 and C tumors with a small number (one to three) of lymph nodes with metastatic deposits. The DNA nondiploid cancers also had a relatively poorer prognosis in patients with unresectable disease. In a Cox multivariate analysis model, the DNA pattern was an independent prognostic variable for this group of 264 patients with resected colorectal carcinoma.

(Arch Surg 1987;122:1375-1379)

×