• Sixteen patients with septic complications of severe thermal injury were studied with respect to neutrophil intracellular—killing power against clinical isolates from the patients themselves and against other laboratory organisms. Simultaneous measurements of neutrophil chemotaxis, helper/suppressor lymphocyte ratios, and serum IgG concentrations were also carried out. Neutrophils from patients who survived had diminished intracellular-killing capacity for their own organisms, but normal capacity for killing laboratory organisms either matched or unmatched with the patients' own isolate's species. In these patients, the chemotactic index, the lymphocyte helper/suppressor ratio, and the serum IgG concentration remained within normal limits. Neutrophils from patients who died failed to kill their own, as well as laboratory, organisms. In these patients, the chemotactic index, lymphocyte helper/suppressor ratio, and IgG concentration were significantly diminished. The biological implications of these findings are noted.
(Arch Surg 1988;123:686-688)
Moran KT, Allo MM, O'Reilly TJ, Karadsheh DF, Munster AM. Neutrophil Intracellular Kill Following Thermal InjuryDifferent Bactericidal Capability for Patients' Organisms and Laboratory Organisms. Arch Surg. 1988;123(6):686-688. doi:10.1001/archsurg.1988.01400300028002