To the Editor.—We read with interest the study by Franson et al1 that reported five cases of Pneumocystis carinii pneumonia (PCP) among 11 renal transplant recipients receiving cyclosporine-prednisone immunosuppression. They concluded that cyclosporine immunosuppression may be related to the development of PCP. We would like to report our experience among 227 cyclosporine-treated renal transplant recipients who received cyclosporine-prednisone immunosuppression, 55 of whom developed diffuse interstitial infiltrates and underwent bronchial alveolar lavage and bronchial brushings as part of a standard protocol to diagnose pulmonary infections in transplant recipients.
Patients and Methods.—We observed nine (4%) of 227 cyclosporine-treated patients who had PCP from February 1985, to May 1987, before we routinely instituted prophylactic trimethoprim-sulfamethoxazole prophylaxis during the first six months after transplantation. This incidence is similar to that in a previous report from our institution.2Pneumocystis carinii pneumonia occurred an average of 97 days (range, 53 to 133
JOHNSON PC, LEWIS RM, VAN BUREN CT, KAHAN BD. Pneumocystis carinii Pneumonia in Renal Transplant Recipients. Arch Surg. 1988;123(7):912-913. doi:10.1001/archsurg.1988.01400310126026