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November 1988

Effect of Ibuprofen and Interleukin 2 on Transfusion-Induced Suppression of Cell-Mediated Immunity

Author Affiliations

From the Department of Surgery, University of Utah Medical Center, Salt Lake City.

Arch Surg. 1988;123(11):1397-1399. doi:10.1001/archsurg.1988.01400350111017

• Transfusion-induced immunosuppression has been associated with excessive production of prostaglandin E and decreased interleukin 2 (IL-2) production. In the present study, allogeneic blood—transfused mice were tested for cell-mediated immunity with the use of a delayed-type hypersensitivity assay. In vivo administration of a cyclo-oxygenase inhibitor, ibuprofen, and murine recombinant IL-2 was initiated on day 0 and continued daily throughout the delayed-type hypersensitivity assay. The results indicate that prostaglandin E may play a primary role in allogeneic blood transfusion—induced suppression, as manifest by normal responses in ibuprofentreated mice. Supplementation of transfused mice with recombinant IL-2 also preserved immune response, indicating inadequate IL-2 production after transfusion, while receptor expression appears to remain intact.

(Arch Surg 1988;123:1397-1399)