April 1989

Common Bile Duct HealingDo Different Absorbable Sutures Affect Stricture Formation and Tensile Strength?

Author Affiliations

From the Departments of Surgery, Nashville Veterans Administration Medical Center (Drs Sharp, Ross, and Dunn), and Vanderbilt University Medical Center (Drs Sharp, Ross, and Dunn and Ms Tillman), Nashville, Tenn.

Arch Surg. 1989;124(4):408-414. doi:10.1001/archsurg.1989.01410040018003

• Few basic investigations have addressed the problem of common bile duct strictures. We systematically investigated the healing canine end-to-end choledochal anastomosis and tested the hypothesis that common bile duct anastomoses sutured with monofilament polyglyconate absorbable suture would heal with less stricture formation and greater tensile strength than those sutured with braided polyglactin 910 and chromic catgut sutures. Seventy-six canines, randomized to control vs sutured groups, underwent either mobilization (controls) or transection of the mid—common bile duct and were allowed to heal 5, 10, 15, or 50 days postoperatively before sacrifice. The type of absorbable suture used to construct a common bile duct anastomosis was found to have no major effect on anastomotic strictures nor on anastomotic breaking strength. Polyglyconate suture caused significantly less perianastomotic inflammation than did chromic suture, with polyglactin 910 sutures evoking an intermediate inflammatory response. Surgeons may safely choose sutures for biliary procedures based on the clinical circumstances and personal preference.

(Arch Surg. 1989;124:408-414)