• Shock increases the propensity to develop infection after injury or operation. This study evaluated the effect of cefoxitin, interferon gamma (INF-γ), and tumor necrosis factor alpha (TNF-α) on the development of a polymicrobial soft-tissue infection. After sham operation or hemorrhagic shock and resuscitation, Sprague-Dawley rats were inoculated with 1 × 108Escherichia coli and 1 × 109Bacteroides fragilis in a 5% fecal suspension. Animals received either no treatment, cefoxitin, recombinant rat INF-γ, recombinant human TNF-α, or cefoxitin/cytokine combinations. Cefoxitin reduced abscess size by 57% in animals without shock but only by 26% after shock. Although neither INF-γ nor TNF-α alone had a salutary effect when given with cefoxitin in animals after shock, INF-γ and TNF-α reduced abscess size by 50% and 55%, respectively. These results suggest that INF-γ and TNF-α may be useful to reduce the severity of mixed gram-negative infections after shock with bacterial contamination.
(Arch Surg. 1990;125:444-446)
Malangoni MA, Livingston DH, Sonnenfeld G, Polk HC. Interferon Gamma and Tumor Necrosis Factor AlphaUse in Gram-negative Infection After Shock. Arch Surg. 1990;125(4):444-446. doi:10.1001/archsurg.1990.01410160030005