April 1990

Neutrophil Chemotactic Activity in Human Gastric Secretions

Author Affiliations

From the Departments of Surgery (Drs Kozol, Punzo, and Elgebaly), Pathology (Dr Ribaudo), and Biostructure and Function (Dr Rossomando), University of Connecticut Health Science Center, Farmington, and Newington (Conn) Veterans Administration Hospital. Dr Kozol is now with the Surgical Service, Veterans Administration Medical Center, Allen Park, Mich.

Arch Surg. 1990;125(4):454-456. doi:10.1001/archsurg.1990.01410160040008

• To study levels of neutrophil chemotactic activity in human gastric secretions, these secretions were collected via the endoscope during elective esophagogastroduodenoscopy. Fresh samples were then prepared for the neutrophil chemotactic assay with the use of human peripheral neutrophils in modified Boyden chambers. Mean maximum chemotactic activity was 45.8%±11.2% in patients with gastric inflammation compared with only 10.1%±4.2% in patients with normal results of endoscopic examination. The chemotactic factors responsible for this chemotactic activity may play a role in the recruitment of neutrophils to areas of gastric mucosal injury.

(Arch Surg. 1990;125:454-456)