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Article
May 1990

Neutrophil Activation in Acute Renal Failure and Sepsis

Author Affiliations

From the Department of Medicine, Division of Nephrology, University of Freiburg (Federal Republic of Germany) (Dr W. H. Hörl), and the Department of Medicine, Division of Nephrology (Drs Schäfer and Heidland), and Department of Surgery (Dr M. Hörl), University of Würzburg (Federal Republic of Germany).

Arch Surg. 1990;125(5):651-654. doi:10.1001/archsurg.1990.01410170099021
Abstract

• Neutrophils are activated during sepsis. To find out whether granulocytes are further activated during hemodialysis with cellulosic and noncellulosic membranes, we compared the plasma levels of the main granulocyte components in patients with chronic uremia who were undergoing regular hemodialysis treatment and patients with acute renal failure with and without sepsis. During hemodialysis with cuprophane dialyzers, plasmagranulocyte elastase, in complex with α-proteinase inhibitor, and lactoferrin levels increased in patients who were undergoing regular hemodialysis treatment, but these levels increased further in patients with acute renal failure who did not have sepsis. Maximal neutrophil degranulation was observed in patients with acute renal failure and sepsis. There was only mild degranulation in all three groups during dialysis with dialyzers made of polysulfone. Our data demonstrate that neutrophil activation is increased in patients with acute renal failure, and it is increased further by superimposed sepsis. Cellulose-containing dialysis membranes introduce a further activation of neutrophils.

(Arch Surg. 1990;125:651-654)

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