October 1991

Effect of Donor-Disseminated Intravascular Coagulation in Liver Transplantation

Author Affiliations

From the Departments of Surgery (Drs Cheng and Crass) and Clinical Pathology (Dr Johnson), Oregon Health Sciences University, Portland; Portland (Ore) Veterans Affairs Medical Center (Drs Cheng, Crass, and Johnson); and the Department of Surgery (Drs Pinson and Lopez), Vanderbilt University Medical School, Nashville, Tenn.

Arch Surg. 1991;126(10):1292-1296. doi:10.1001/archsurg.1991.01410340134019

• It is not known whether disseminated intravascular coagulation, present in a large percentage of organ donors, affects patient outcome after liver transplantation. We reviewed our first 55 liver transplantations and identified 10 donors with disseminated intravascular coagulation. We compared the perioperative courses of the 10 recipients of these transplanted livers with those of 10 matched controls whose donors did not have disseminated intravascular coagulation. Disseminated intravascular coagulation recipients did not require more blood products during or after surgery; their hepatic enzyme levels and prothrombin times after surgery were not statistically significantly higher than those of the controls. There was no difference in hospital stay, number of episodes of rejection, retransplantations, or deaths. The presence of disseminated intravascular coagulation in donors did not adversely affect graft function or patient outcome and should not be a sole criterion for rejecting a liver for transplantation.

(Arch Surg. 1991;126:1292-1296)