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Article
February 1992

Candida Infection With and Without Nystatin ProphylaxisAn 11-Year Experience With Patients With Burn Injury

Author Affiliations

From the Shriners Burns Institute—Galveston (Drs Desai, Heggers, and Herndon and Ms Rutan), and the University of Texas Medical Branch, Galveston (Drs Desai, Heggers, and Herndon).

Arch Surg. 1992;127(2):159-162. doi:10.1001/archsurg.1992.01420020041006
Abstract

• The incidence of opportunistic infections after thermal injury is high. Since 1985, we have been practicing Candida prophylaxis using nystatin "swish-and-swallow" and topical therapy. Patients treated between 1980 and 1984 served as controls and received no Candida prophylaxis. Although mean burn size, full-thickness injury, and age were comparable, the incidence of Candida colonization (26.7% vs 15.6%), infection (21.3% vs 10.0%), and sepsis (12.2% vs none) was significantly different between control and nystatin-treated groups, respectively. With prophylaxis, the incidence of Candida wound infection has been significantly reduced, and systemic candidiasis has been eradicated, eliminating the need for toxic systemic antifungal agents.

(Arch Surg. 1992;127:159-162)

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